Mathews trailed by 12 points at intermission (44-32), the Mustangs outscored Western Reserve 32-21 in the final sixteen minutes only to fall 1 point short of the Blue Devils, 65-64.
Mathews' Cole O'Dell poured in 27 points and Zach Youngs had 19. The Mustangs drop to 5-2.
Western Reserve was paced by Thomas Benyo's 26. Reserve improves to 4-1.